Climate change is affecting small-scale farmers in developing countries. Numerous studies on climate change suggest that climate variability is expected to increase in the next few decades, and that it is likely to be severe for tropical areas. In Cameroon, small scale farmers are the most vulnerable group since the ecosystems they depend upon to grow food are at risk, and many lack the adaptive capacities to cope with more extreme weather conditions. These changes affect their livelihoods and poses challenges for food security and economic development. Appraising innovative and adaptive approaches for the mitigation of climate change effects on small scale farmers’ livelihoods in five agro ecological zones of Cameroon, will enhance sustainable livelihoods. The results of the research will boost intervention strategies that are capable to stabilize the livelihoods of small scale farmers and reduce vulnerability. This study will use the Participatory rural appraisal tools to collect data that will be analyzed using the livelihoods conceptual framework. This study will also contribute to awareness creation, provide information on the innovation and adaptation strategies, new knowledge and skills in the mitigation of the dynamics of climate change. The study will be of benefit to small scale farmers, students, development organizations, the researcher, government technical services and other stake holders in the domain of development.