This study aims to analyze the effect of interest rates, inflation and national income on the rupiah exchange rate on the US dollar. The data used in this study is secondary data, with the type of time series data in the period 2006-2016 obtained from Bank Indonesia and World Bank. This research method using expose facto method. Data analysis technique used in this research is multiple regression analysis. Using multiple regression analysis model, the output shows that the interest rate (X1) has a positive and significant effect on the rupiah exchange rate of US dollar (Y). The inflation rate (X2) has no significant effect on the rupiah exchange rate on the US dollar (Y). The national income (X3) has a positive effect on the rupiah exchange rate on the US dollar (Y). From the result of F test by seeing the significance value = 0,000 <0,05 it can be said simultaneously interest rate, inflation and national income have significant effect on α = 5% to rupiah exchange rate of US dollar in year 2006-2016. The value of determination coefficient (R2) obtained by 0.660 has the understanding that the exchange rate of the rupiah exchange rate against the US dollar can be explained by the interest rate, inflation and national income of 66% while the rest is explained by other factors not present in this research model.